Hyzaar is a brand-name medication that contains two active ingredients: losartan potassium and hydrochlorothiazide (HCTZ). Losartan works by relaxing blood vessels, making it easier for blood to flow. Hydrochlorothiazide helps the body remove excess fluid and salt through urination, further reducing blood pressure. The combination therapy is especially effective for patients who need more than one type of medication to manage their hypertension. Available strengths include 50 mg/12.5 mg and 100 mg/25 mg tablets. The benefits of Hyzaar include better blood pressure control, reduced risk of cardiovascular complications, and protection against kidney damage in patients with diabetes.